Assay Detail
ADMET
CHEMBL3253381
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Anticholinergic effect in guinea pig ileum assessed as inhibition of acetylcholine-induced contraction
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted 3-amino-1,1-diaryl-2-propanols as potential antidepressant agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 5.40 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 8.90 |
| CHEMBL3251022 | — | — | 1 | 5.80 |
| CHEMBL3250724 | — | — | 1 | 5.50 |
| CHEMBL3250723 | — | — | 1 | 5.20 |
| CHEMBL3250733 | — | — | 1 | 5.20 |
| CHEMBL3250719 | — | — | 1 | 5.10 |
| CHEMBL528488 | — | — | 1 | 5.10 |
| CHEMBL525281 | — | — | 1 | 5.10 |
| CHEMBL3250721 | — | — | 1 | 5.00 |
| CHEMBL3250734 | — | — | 1 | 4.80 |
| CHEMBL3251020 | — | — | 1 | 4.80 |
| CHEMBL3250725 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL3251022 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL3250724 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL3250723 | — | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL3250733 | — | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL3250719 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL528488 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL525281 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL3250721 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL3250734 | — | Kd | = | 15848.93 | nM | 4.80 |
| CHEMBL3251020 | — | Kd | = | 15848.93 | nM | 4.80 |
| CHEMBL3250725 | — | Kd | = | 50118.72 | nM | 4.30 |