Assay Detail

CHEMBL3255437

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of (-)-[3H]dihydroalprenolol from beta adrenergic receptor in frog erythrocyte membrane after 10 mins by liquid scintillation counting analysis

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Anura
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Structure and biological activity of (-)-[3H]dihydroalprenolol, a radioligand for studies of beta-adrenergic receptors.

Randall MH, Altman LJ, Lefkowitz RJ.
J Med Chem (1977) 20 : 1090 -1094
PubMed 197238 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	8.60	8.60

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3249366	—	—	1	8.60
CHEMBL1159723	—	—	1	8.60

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3249366	—	Kd	=	2.5	nM	8.60
CHEMBL1159723	—	Kd	=	2.5	nM	8.60