Assay Detail
Binding
CHEMBL3256336
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Antagonist activity at beta2 adrenoceptor in guinea pig trachea assessed as inhibition of isoproterenol-induced response after 20 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Methoxyphenylethanolamines, potential beta-adrenergic blocking agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 6.47 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.86 |
| CHEMBL3246228 | — | — | 1 | 7.87 |
| CHEMBL3246226 | — | — | 1 | 6.92 |
| CHEMBL3246227 | — | — | 1 | 6.70 |
| CHEMBL3246231 | — | — | 1 | 6.50 |
| CHEMBL3246232 | — | — | 1 | 6.40 |
| CHEMBL3246230 | — | — | 1 | 6.03 |
| CHEMBL3246229 | — | — | 1 | 5.90 |
| CHEMBL24 | ATENOLOL | 4.0 | 1 | 5.90 |
| CHEMBL3246233 | — | — | 1 | 5.70 |
| CHEMBL3246235 | — | — | 1 | 5.60 |
| CHEMBL6995 | PRACTOLOL | 4.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | Kd | = | 1.38 | nM | 8.86 |
| CHEMBL3246228 | — | Kd | = | 13.49 | nM | 7.87 |
| CHEMBL3246226 | — | Kd | = | 120.23 | nM | 6.92 |
| CHEMBL3246227 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL3246231 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL3246232 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL3246230 | — | Kd | = | 933.25 | nM | 6.03 |
| CHEMBL3246229 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL24 | ATENOLOL | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL3246233 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL3246235 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL6995 | PRACTOLOL | Kd | = | 6309.57 | nM | 5.20 |