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Assay Detail

CHEMBL3257006

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of thrombin (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships for the inhibition of acrosin by benzamidine derivatives.
Parrish RF, Straus JW, Paulson JD, Polakoski KL, Tidwell RR, Geratz JD, Stevens FM.
J Med Chem (1978) 21 : 1132 -1136
PubMed 722718 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 5.34 6.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3245421 1 6.19
CHEMBL2418042 1 4.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3245421 Ki = 651.0 nM 6.19
CHEMBL2418042 Ki = 32400.0 nM 4.49