Assay Detail
Functional
CHEMBL3257692
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In vivo inhibition of beta-1 adrenoceptor in vagotomized cat assessed as inhibition of isoproterenol-induced tachycardia
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Felis catus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alteration of relative affinities toward myocardial and vascular beta adrenoceptors induced by side-chain substitution of aryloxypropanolamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.63 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7154 | — | — | 1 | 7.35 |
| CHEMBL3251779 | — | — | 1 | 7.20 |
| CHEMBL3251781 | — | — | 1 | 6.66 |
| CHEMBL6995 | PRACTOLOL | 4.0 | 1 | 6.64 |
| CHEMBL67151 | — | — | 1 | 6.63 |
| CHEMBL3251780 | — | — | 1 | 6.30 |
| CHEMBL3251782 | — | — | 1 | 5.66 |
| CHEMBL3251783 | — | — | 1 | - |
| CHEMBL3251784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7154 | — | Kd | = | 44.67 | nM | 7.35 |
| CHEMBL3251779 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL3251781 | — | Kd | = | 218.78 | nM | 6.66 |
| CHEMBL6995 | PRACTOLOL | Kd | = | 229.09 | nM | 6.64 |
| CHEMBL67151 | — | Kd | = | 234.42 | nM | 6.63 |
| CHEMBL3251780 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL3251782 | — | Kd | = | 2187.76 | nM | 5.66 |
| CHEMBL3251783 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL3251784 | — | Kd | > | 10000.0 | nM | - |