Assay Detail
Binding
CHEMBL3258702
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Antagonist activity at angiotensin 2 receptor in rabbit aortic strip assessed as inhibition of contractile activity
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of [1-sarcosine, 8-O-methylserine]angiotensin II and 1-substituted analogues of [8-threonine]angiotensin II as antagonists of angiotensin II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.17 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3250430 | — | — | 1 | 9.66 |
| CHEMBL2371400 | — | — | 1 | 8.79 |
| CHEMBL3248823 | — | — | 1 | 8.76 |
| CHEMBL3250152 | — | — | 1 | 7.68 |
| CHEMBL3250153 | — | — | 1 | 7.53 |
| CHEMBL3250155 | — | — | 1 | 7.53 |
| CHEMBL3250154 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3250430 | — | Kd | = | 0.2188 | nM | 9.66 |
| CHEMBL2371400 | — | Kd | = | 1.622 | nM | 8.79 |
| CHEMBL3248823 | — | Kd | = | 1.738 | nM | 8.76 |
| CHEMBL3250152 | — | Kd | = | 20.89 | nM | 7.68 |
| CHEMBL3250153 | — | Kd | = | 29.51 | nM | 7.53 |
| CHEMBL3250155 | — | Kd | = | 29.51 | nM | 7.53 |
| CHEMBL3250154 | — | Kd | = | 58.88 | nM | 7.23 |