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Compound Detail

CHEMBL3250152

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CC[C@H](C)[C@H](NC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)CC)C(C)C

Basic Information

ChEMBL ID CHEMBL3250152
Phase Preclinical
Structure Type BOTH
InChI Key GMQGUUVYERLGLB-ZNPGMMQLSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

1012.2
MW (Da)

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C48H77N13O11
MW 1012.22

Activity Summary

Kd 1 meas. best 7.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 7.68 7.68 20.9 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Kd = 20.89 nM 7.68 Antagonist activity at angiotensin 2 receptor in rabbit aortic strip assessed as... 836496

Literature References

PubMed DOI Target Context # Activities
836496 10.1021/jm00212a013 Rattus norvegicus 6
836496 10.1021/jm00212a013 Unchecked 2

Data from ChEMBL 36 via Core Engine