Assay Detail
Binding
CHEMBL3265576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Syk in alphaIgM-stimulated human B cells assessed as cell proliferation after 1 hr incubation by flow cytometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | B |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.11 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3265032 | ENTOSPLETINIB | 3.0 | 1 | 7.39 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3265032 | ENTOSPLETINIB | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL475251 | R-406 | EC50 | = | 151.0 | nM | 6.82 |