Assay Detail
Binding
CHEMBL3265752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MAP4K4 using 5-FAM-LGRDKYKTLRQIRQ-COOH as substrate by Z'-LYTE assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 4 (CHEMBL6166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.54 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262587 | — | — | 1 | 7.77 |
| CHEMBL3262580 | — | — | 1 | 7.24 |
| CHEMBL3262579 | — | — | 1 | 7.22 |
| CHEMBL3262583 | — | — | 1 | 7.11 |
| CHEMBL3262570 | — | — | 1 | 6.92 |
| CHEMBL3262584 | — | — | 1 | 6.88 |
| CHEMBL3262569 | — | — | 1 | 6.72 |
| CHEMBL3262575 | — | — | 1 | 6.65 |
| CHEMBL3262581 | — | — | 1 | 6.53 |
| CHEMBL3262572 | — | — | 1 | 6.48 |
| CHEMBL3262578 | — | — | 1 | 6.46 |
| CHEMBL3262582 | — | — | 1 | 6.42 |
| CHEMBL3262577 | — | — | 1 | 6.41 |
| CHEMBL3262574 | — | — | 1 | 6.37 |
| CHEMBL3262571 | — | — | 1 | 6.26 |
| CHEMBL3262573 | — | — | 1 | 6.16 |
| CHEMBL3262576 | — | — | 1 | 5.77 |
| CHEMBL3262586 | — | — | 1 | 5.67 |
| CHEMBL3262585 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262587 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3262580 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3262579 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3262583 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3262570 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL3262584 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL3262569 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL3262575 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL3262581 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL3262572 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3262578 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL3262582 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL3262577 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL3262574 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL3262571 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL3262573 | — | IC50 | = | 689.0 | nM | 6.16 |
| CHEMBL3262576 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3262586 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL3262585 | — | IC50 | = | 5840.0 | nM | 5.23 |