Compound Detail
CHEMBL3262571
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Basic Information
| ChEMBL ID | CHEMBL3262571 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CUSAKFRCIPMPMS-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
251.3
MW (Da)
2.89
ALogP
4
HBA
1
HBD
61.0
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase kinase 4 CHEMBL6166 | IC50 | 6.26 | 6.1667 | 546.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 17.0 | mL.min-1.kg-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase kinase 4 | IC50 | = | 546.0 | nM | 6.26 | Inhibition of human MAP4K4 using 5-FAM-LGRDKYKTLRQIRQ-COOH as substrate by Z'-LY... | 24673130 |
| Mitogen-activated protein kinase kinase kinase kinase 4 | IC50 | = | 751.0 | nM | 6.12 | MAP4K4 Inhibition Assay: The kinase activity of purified human MAP4K4 kinase dom... | - |
| Mitogen-activated protein kinase kinase kinase kinase 4 | IC50 | = | 751.0 | nM | 6.12 | Inhibition Assay: The kinase activity of purified human MAP4K4 kinase domain was... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24673130 | 10.1021/jm500155b | Mitogen-activated protein kinase kinase kinase kinase 4 | 1 |
| 24673130 | 10.1021/jm500155b | Liver microsome | 1 |
| 24673130 | 10.1021/jm500155b | Liver | 1 |
Data from ChEMBL 36 via Core Engine