Assay Detail
Binding
CHEMBL3266003
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Antagonist activity at progesterone receptor (unknown origin) by Gal4-based cellular assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.82 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215331 | PF-03882845 | 1.0 | 1 | 6.38 |
| CHEMBL3263760 | — | — | 1 | 6.31 |
| CHEMBL3263764 | — | — | 1 | 6.26 |
| CHEMBL3263763 | — | — | 1 | 6.22 |
| CHEMBL3263768 | — | — | 1 | 6.17 |
| CHEMBL3263758 | — | — | 1 | 6.09 |
| CHEMBL3263767 | — | — | 1 | 6.08 |
| CHEMBL1215130 | — | — | 1 | 5.99 |
| CHEMBL3263762 | — | — | 1 | 5.83 |
| CHEMBL3263765 | — | — | 1 | 5.82 |
| CHEMBL3263754 | — | — | 1 | 5.80 |
| CHEMBL1215197 | — | — | 1 | 5.70 |
| CHEMBL3263759 | — | — | 1 | 5.69 |
| CHEMBL3263751 | — | — | 1 | 5.66 |
| CHEMBL3263766 | — | — | 1 | 5.61 |
| CHEMBL3263752 | — | — | 1 | 5.60 |
| CHEMBL3263757 | — | — | 1 | 5.58 |
| CHEMBL3263750 | — | — | 1 | 5.57 |
| CHEMBL3263761 | — | — | 1 | 5.43 |
| CHEMBL3263756 | — | — | 1 | 5.28 |
| CHEMBL3263755 | — | — | 1 | 5.17 |
| CHEMBL3263753 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215331 | PF-03882845 | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL3263760 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL3263764 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3263763 | — | IC50 | = | 597.0 | nM | 6.22 |
| CHEMBL3263768 | — | IC50 | = | 684.0 | nM | 6.17 |
| CHEMBL3263758 | — | IC50 | = | 806.0 | nM | 6.09 |
| CHEMBL3263767 | — | IC50 | = | 831.0 | nM | 6.08 |
| CHEMBL1215130 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3263762 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL3263765 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL3263754 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL1215197 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL3263759 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL3263751 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL3263766 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL3263752 | — | IC50 | = | 2529.0 | nM | 5.60 |
| CHEMBL3263757 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3263750 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL3263761 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL3263756 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL3263755 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL3263753 | — | IC50 | - | — | - |