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Assay Detail

CHEMBL3266157

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Functional
Antagonist activity at recombinant human EBI2 receptor expressed in CHO cells assessed as inhibition of NIBR51-induced intracellular calcium release measured for 3 mins by FLIPR assay
ChEMBL ↗
44
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

G-protein coupled receptor 183 (CHEMBL3259470) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.
Gessier F, Preuss I, Yin H, Rosenkilde MM, Laurent S, Endres R, Chen YA, Marsilje TH, Seuwen K, Nguyen DG, Sailer AW.
J Med Chem (2014) 57 : 3358 -3368
PubMed 24678947 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 7.45 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3262895 — — 2 8.30
CHEMBL3262896 — — 2 7.98
CHEMBL3262892 — — 2 7.89
CHEMBL3262894 — — 2 7.80
CHEMBL3262883 — — 2 7.77
CHEMBL3262890 — — 2 7.77
CHEMBL3262891 — — 2 7.75
CHEMBL3262880 — — 2 7.72
CHEMBL3262889 — — 2 7.72
CHEMBL3262879 — — 2 7.68
CHEMBL3262882 — — 2 7.62
CHEMBL3262877 — — 2 7.55
CHEMBL3262881 — — 2 7.54
CHEMBL3262884 — — 2 7.53
CHEMBL3262888 — — 2 7.50
CHEMBL3262887 — — 2 7.40
CHEMBL3262893 — — 2 7.36
CHEMBL3262886 — — 2 7.17
CHEMBL3262885 — — 2 7.01
CHEMBL3262876 — — 2 6.91
CHEMBL1305842 — — 2 6.51
CHEMBL3262878 — — 2 5.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3262895 — IC50 = 5.0 nM 8.30
CHEMBL3262895 — IC50 = 5.012 nM 8.30
CHEMBL3262896 — IC50 = 10.47 nM 7.98
CHEMBL3262896 — IC50 = 11.0 nM 7.96
CHEMBL3262892 — IC50 = 12.88 nM 7.89
CHEMBL3262892 — IC50 = 13.0 nM 7.89
CHEMBL3262894 — IC50 = 16.0 nM 7.80
CHEMBL3262894 — IC50 = 15.85 nM 7.80
CHEMBL3262883 — IC50 = 17.0 nM 7.77
CHEMBL3262883 — IC50 = 16.98 nM 7.77
CHEMBL3262890 — IC50 = 17.0 nM 7.77
CHEMBL3262890 — IC50 = 16.98 nM 7.77
CHEMBL3262891 — IC50 = 18.0 nM 7.75
CHEMBL3262891 — IC50 = 18.2 nM 7.74
CHEMBL3262889 — IC50 = 19.05 nM 7.72
CHEMBL3262880 — IC50 = 19.05 nM 7.72
CHEMBL3262880 — IC50 = 19.0 nM 7.72
CHEMBL3262889 — IC50 = 19.0 nM 7.72
CHEMBL3262879 — IC50 = 21.0 nM 7.68
CHEMBL3262879 — IC50 = 20.89 nM 7.68
CHEMBL3262882 — IC50 = 24.0 nM 7.62
CHEMBL3262882 — IC50 = 23.99 nM 7.62
CHEMBL3262877 — IC50 = 28.18 nM 7.55
CHEMBL3262877 — IC50 = 28.0 nM 7.55
CHEMBL3262881 — IC50 = 29.0 nM 7.54
CHEMBL3262881 — IC50 = 28.84 nM 7.54
CHEMBL3262884 — IC50 = 29.51 nM 7.53
CHEMBL3262884 — IC50 = 31.0 nM 7.51
CHEMBL3262888 — IC50 = 32.0 nM 7.50
CHEMBL3262888 — IC50 = 32.36 nM 7.49
CHEMBL3262887 — IC50 = 39.81 nM 7.40
CHEMBL3262887 — IC50 = 40.0 nM 7.40
CHEMBL3262893 — IC50 = 44.0 nM 7.36
CHEMBL3262893 — IC50 = 43.65 nM 7.36
CHEMBL3262886 — IC50 = 67.61 nM 7.17
CHEMBL3262886 — IC50 = 71.0 nM 7.15
CHEMBL3262885 — IC50 = 97.72 nM 7.01
CHEMBL3262885 — IC50 = 98.0 nM 7.01
CHEMBL3262876 — IC50 = 123.03 nM 6.91
CHEMBL3262876 — IC50 = 196.0 nM 6.71
CHEMBL1305842 — IC50 = 309.03 nM 6.51
CHEMBL1305842 — IC50 = 330.0 nM 6.48
CHEMBL3262878 — IC50 = 2951.21 nM 5.53
CHEMBL3262878 — IC50 = 2934.0 nM 5.53