Assay Detail
Binding
CHEMBL3266322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (+)-[3H]pentazocine from Dunkin guinea pig brain sigma 1 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.38 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 8.58 |
| CHEMBL3259962 | — | — | 1 | 8.27 |
| CHEMBL3259961 | — | — | 1 | 6.81 |
| CHEMBL3259963 | — | — | 1 | 6.63 |
| CHEMBL3259960 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 2.62 | nM | 8.58 |
| CHEMBL3259962 | — | Ki | = | 5.37 | nM | 8.27 |
| CHEMBL3259961 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL3259963 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL3259960 | — | Ki | = | 258.0 | nM | 6.59 |