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Assay Detail

CHEMBL3266489

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type ASPC1
Confidence 1 — Organism
Curated By Autocuration

Target

ASPC1 (CHEMBL612588)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents.
Fei X, Jo M, Lee B, Han SB, Lee K, Jung JK, Seo SY, Kwak YS.
Bioorg Med Chem Lett (2014) 24 : 2062 -2065
PubMed 24717154 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.87 5.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 5.73
CHEMBL323197 MANGOSTIN 1 5.40
CHEMBL3261720 1 5.33
CHEMBL260553 1 5.23
CHEMBL3261722 1 4.89
CHEMBL3261713 1 4.86
CHEMBL3261709 1 4.86
CHEMBL3261716 1 4.86
CHEMBL465553 1 4.85
CHEMBL3261723 1 4.71
CHEMBL3261712 1 4.67
CHEMBL561643 MANGOSTANIN 1 4.59
CHEMBL3261715 1 4.59
CHEMBL3261719 1 4.50
CHEMBL3261721 1 4.50
CHEMBL3261710 1 4.28
CHEMBL3261711 1 -
CHEMBL463293 1 -
CHEMBL3261714 1 -
CHEMBL3261717 1 -
CHEMBL3261718 1 -
CHEMBL464119 1 -
CHEMBL3261724 1 -
CHEMBL3261725 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 1870.0 nM 5.73
CHEMBL323197 MANGOSTIN IC50 = 4020.0 nM 5.40
CHEMBL3261720 IC50 = 4640.0 nM 5.33
CHEMBL260553 IC50 = 5920.0 nM 5.23
CHEMBL3261722 IC50 = 12960.0 nM 4.89
CHEMBL3261713 IC50 = 13760.0 nM 4.86
CHEMBL3261709 IC50 = 13900.0 nM 4.86
CHEMBL3261716 IC50 = 13900.0 nM 4.86
CHEMBL465553 IC50 = 14250.0 nM 4.85
CHEMBL3261723 IC50 = 19260.0 nM 4.71
CHEMBL3261712 IC50 = 21330.0 nM 4.67
CHEMBL561643 MANGOSTANIN IC50 = 25490.0 nM 4.59
CHEMBL3261715 IC50 = 25780.0 nM 4.59
CHEMBL3261719 IC50 = 31340.0 nM 4.50
CHEMBL3261721 IC50 = 31770.0 nM 4.50
CHEMBL3261710 IC50 = 52750.0 nM 4.28
CHEMBL3261711 IC50 > 100000.0 nM -
CHEMBL463293 IC50 > 100000.0 nM -
CHEMBL3261714 IC50 > 100000.0 nM -
CHEMBL3261717 IC50 > 100000.0 nM -
CHEMBL3261718 IC50 > 100000.0 nM -
CHEMBL464119 IC50 > 100000.0 nM -
CHEMBL3261724 IC50 > 100000.0 nM -
CHEMBL3261725 IC50 > 100000.0 nM -