Assay Detail
Functional
CHEMBL3266569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 HxB2 harboring integrase A124/T125 mutant by cell based luciferase reporter gene assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.87 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3259903 | — | — | 1 | 8.70 |
| CHEMBL3259906 | — | — | 1 | 8.22 |
| CHEMBL3259902 | — | — | 1 | 8.15 |
| CHEMBL3259907 | BI-224436 | 1.0 | 1 | 7.96 |
| CHEMBL3259901 | — | — | 1 | 7.89 |
| CHEMBL3259898 | — | — | 1 | 7.64 |
| CHEMBL3259899 | — | — | 1 | 7.58 |
| CHEMBL3259897 | — | — | 1 | 7.57 |
| CHEMBL3259896 | — | — | 1 | 7.55 |
| CHEMBL3259900 | — | — | 1 | 7.51 |
| CHEMBL3259905 | — | — | 1 | 7.47 |
| CHEMBL3259895 | — | — | 1 | 7.11 |
| CHEMBL3259894 | — | — | 1 | 6.89 |
| CHEMBL3259893 | — | — | 1 | 6.35 |
| CHEMBL3259890 | — | — | 1 | 6.04 |
| CHEMBL3259891 | — | — | 1 | 6.00 |
| CHEMBL3259889 | — | — | 1 | 4.89 |
| CHEMBL3259887 | — | — | 1 | 4.80 |
| CHEMBL3259886 | — | — | 1 | 4.70 |
| CHEMBL3259892 | — | — | 1 | 4.33 |
| CHEMBL1422607 | — | — | 1 | - |
| CHEMBL3259888 | — | — | 1 | - |
| CHEMBL3259885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3259903 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3259906 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3259902 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3259907 | BI-224436 | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3259901 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3259898 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3259899 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3259897 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3259896 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3259900 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3259905 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3259895 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3259894 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3259893 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3259890 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3259891 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3259889 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3259887 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3259886 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3259892 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1422607 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL3259888 | — | EC50 | > | 43000.0 | nM | - |
| CHEMBL3259885 | — | EC50 | > | 33000.0 | nM | - |