Assay Detail
Functional
CHEMBL3266570
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4.3 harboring integrase T124/A125 mutant by cell based luciferase reporter gene assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.09 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3259906 | — | — | 1 | 7.68 |
| CHEMBL3259902 | — | — | 1 | 7.66 |
| CHEMBL3259903 | — | — | 1 | 7.66 |
| CHEMBL3259904 | — | — | 1 | 7.54 |
| CHEMBL3259896 | — | — | 1 | 7.16 |
| CHEMBL3259899 | — | — | 1 | 7.04 |
| CHEMBL3259898 | — | — | 1 | 6.96 |
| CHEMBL3259900 | — | — | 1 | 6.92 |
| CHEMBL3259901 | — | — | 1 | 6.89 |
| CHEMBL3259897 | — | — | 1 | 6.80 |
| CHEMBL3259905 | — | — | 1 | 6.52 |
| CHEMBL3259895 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3259906 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3259902 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3259903 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3259904 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3259896 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3259899 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3259898 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3259900 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3259901 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3259897 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3259905 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3259895 | — | EC50 | = | 610.0 | nM | 6.21 |