Assay Detail
Binding
CHEMBL3266757
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Inhibition of purified mouse iNOS assessed as inhibition of nitric oxide-mediated oxidation of hemoglobin-A by hemoglobin capture assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.17 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262022 | — | — | 1 | 5.72 |
| CHEMBL3262024 | — | — | 1 | 5.55 |
| CHEMBL3262025 | — | — | 1 | 5.36 |
| CHEMBL3262019 | — | — | 1 | 5.22 |
| CHEMBL3262026 | — | — | 1 | 5.18 |
| CHEMBL3262018 | — | — | 1 | 4.81 |
| CHEMBL3262017 | — | — | 1 | 4.75 |
| CHEMBL3262023 | — | — | 1 | 4.75 |
| CHEMBL3262020 | — | — | 1 | - |
| CHEMBL3262021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262022 | — | Ki | = | 1894.0 | nM | 5.72 |
| CHEMBL3262024 | — | Ki | = | 2810.0 | nM | 5.55 |
| CHEMBL3262025 | — | Ki | = | 4386.0 | nM | 5.36 |
| CHEMBL3262019 | — | Ki | = | 5990.0 | nM | 5.22 |
| CHEMBL3262026 | — | Ki | = | 6629.0 | nM | 5.18 |
| CHEMBL3262018 | — | Ki | = | 15620.0 | nM | 4.81 |
| CHEMBL3262017 | — | Ki | = | 17670.0 | nM | 4.75 |
| CHEMBL3262023 | — | Ki | = | 17916.0 | nM | 4.75 |
| CHEMBL3262020 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3262021 | — | Ki | > | 100000.0 | nM | - |