Assay Detail
Functional
CHEMBL3267240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glucose-dependent insulinotropic receptor (CHEMBL5652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of structurally novel, potent and orally efficacious GPR119 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 6.92 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260536 | — | — | 1 | 9.00 |
| CHEMBL3260535 | — | — | 1 | 8.40 |
| CHEMBL3260533 | — | — | 1 | 8.00 |
| CHEMBL3260532 | — | — | 1 | 7.96 |
| CHEMBL3260512 | — | — | 1 | 7.80 |
| CHEMBL3260518 | — | — | 1 | 7.77 |
| CHEMBL3260517 | — | — | 1 | 7.70 |
| CHEMBL3260540 | — | — | 1 | 7.70 |
| CHEMBL3260522 | — | — | 1 | 7.40 |
| CHEMBL3260527 | — | — | 1 | 7.40 |
| CHEMBL3260542 | — | — | 1 | 7.28 |
| CHEMBL3260531 | — | — | 1 | 7.24 |
| CHEMBL3260541 | — | — | 1 | 7.21 |
| CHEMBL3260525 | — | — | 1 | 7.20 |
| CHEMBL3260526 | — | — | 1 | 7.14 |
| CHEMBL3260537 | — | — | 1 | 7.07 |
| CHEMBL3260523 | — | — | 1 | 6.96 |
| CHEMBL3260528 | — | — | 1 | 6.89 |
| CHEMBL3260521 | — | — | 1 | 6.85 |
| CHEMBL3260538 | — | — | 1 | 6.79 |
| CHEMBL3260524 | — | — | 1 | 6.77 |
| CHEMBL3260529 | — | — | 1 | 6.75 |
| CHEMBL3260515 | — | — | 1 | 6.72 |
| CHEMBL3260520 | — | — | 1 | 6.72 |
| CHEMBL3260506 | — | — | 1 | 6.70 |
| CHEMBL3260539 | — | — | 1 | 6.61 |
| CHEMBL3260513 | — | — | 1 | 6.54 |
| CHEMBL3260511 | — | — | 1 | 6.47 |
| CHEMBL3260508 | — | — | 1 | 6.25 |
| CHEMBL3260509 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260536 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3260535 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3260533 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3260532 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3260512 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3260518 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3260517 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3260540 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3260522 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3260527 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3260542 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3260531 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3260541 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3260525 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3260526 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3260537 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3260523 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3260528 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3260521 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3260538 | — | EC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3260524 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3260529 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3260520 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3260515 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3260506 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3260539 | — | EC50 | = | 243.0 | nM | 6.61 |
| CHEMBL3260513 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3260511 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3260508 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3260509 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3260543 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3260514 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3260507 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL461384 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3260505 | MBX-2982 | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3260504 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1081913 | — | EC50 | = | 630000.0 | nM | - |
| CHEMBL3260510 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3260516 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3260519 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3260530 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3260534 | — | EC50 | > | 300.0 | nM | - |