Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL3260505

MBX-2982
🧪 Phase II
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
🧪 Phase II
CCc1cnc(N2CCC(c3nc(COc4ccc(-n5cnnn5)cc4)cs3)CC2)nc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL3260505
Name MBX-2982
Phase Phase II
Structure Type MOL
InChI Key NFTMKHWBOINJGM-UHFFFAOYSA-N

Known Names

Mbx-2982
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
20
Publications
1
Known Names
2
Indications
1
Mechanisms

Molecular Properties

448.6
MW (Da)
3.43
ALogP
10
HBA
0
HBD
94.7
PSA (Ų)
0.42
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product

Extended Properties

Molecular Formula C22H24N8OS
MW 448.56
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -2.34

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Glucose-dependent insulinotropic receptor agonist AGONIST Glucose-dependent insulinotropic receptor ✓ ✓

Indications

Diabetes Mellitus Diabetes Mellitus, Type 1

Activity Summary

EC50 5 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 EC50 8.7 8.7 2.0 1
Glucose-dependent insulinotropic receptor
CHEMBL5652
 EC50 8.51 7.32 3.1 4

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 2.0 nM 8.7 Agonist activity at GPR119 in Golden hamster HIT-T15 cells assessed as increase ... 37356344
Glucose-dependent insulinotropic receptor EC50 = 3.1 nM 8.51 Agonist activity at human GPR119 expressed in CHO-K1 cells preincubated for 5 hr... 37356344
Glucose-dependent insulinotropic receptor EC50 = 3.9 nM 8.41 Agonist activity at GPR119 (unknown origin) assessed as increase in cAMP level b... 31898998
Glucose-dependent insulinotropic receptor EC50 = 87.0 nM 7.06 Agonist activity at human GPR119 expressed in CHOK1 cells co-expressing CRE-luci... 29103971
Glucose-dependent insulinotropic receptor EC50 = 5000.0 nM 5.3 Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulat... 24751443

Literature References

PubMed DOI Target Context # Activities
31898998 10.1016/j.bmcl.2019.126855 Mus musculus 5
29103971 10.1016/j.bmcl.2017.10.046 Glucose-dependent insulinotropic receptor 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
31898998 10.1016/j.bmcl.2019.126855 Glucose-dependent insulinotropic receptor 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
29103971 10.1016/j.bmcl.2017.10.046 ADMET 2
24751443 10.1016/j.bmcl.2014.03.023 Glucose-dependent insulinotropic receptor 2
29103971 10.1016/j.bmcl.2017.10.046 Cytochrome P450 2C19 1
29103971 10.1016/j.bmcl.2017.10.046 Cytochrome P450 2D6 1
29103971 10.1016/j.bmcl.2017.10.046 Cytochrome P450 3A4 1
29103971 10.1016/j.bmcl.2017.10.046 Voltage-gated inwardly rectifying potassium channel KCNH2 1
29103971 10.1016/j.bmcl.2017.10.046 Vero 1
29103971 10.1016/j.bmcl.2017.10.046 L929 1
29103971 10.1016/j.bmcl.2017.10.046 NIH3T3 1
29103971 10.1016/j.bmcl.2017.10.046 HFL1 1
29103971 10.1016/j.bmcl.2017.10.046 CHO-K1 1
29103971 10.1016/j.bmcl.2017.10.046 Mus musculus 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
37356344 10.1016/j.ejmech.2023.115584 Rattus norvegicus 1
29103971 10.1016/j.bmcl.2017.10.046 Cytochrome P450 2A6 1

Data from ChEMBL 36 via Core Engine