Assay Detail
Binding
CHEMBL3267340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human recombinant adenosine A1 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Adenosine A2A receptor as a drug discovery target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.53 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285819 | — | — | 1 | 8.86 |
| CHEMBL464859 | NECA | — | 1 | 7.85 |
| CHEMBL3350613 | — | — | 1 | 7.22 |
| CHEMBL1950649 | APADENOSON | 3.0 | 1 | 7.11 |
| CHEMBL331372 | CGS-21680 | — | 1 | 6.54 |
| CHEMBL186113 | GW-328267 | 1.0 | 1 | 6.43 |
| CHEMBL317052 | REGADENOSON ANHYDROUS | 4.0 | 1 | 5.42 |
| CHEMBL1950553 | SONEDENOSON | 2.0 | 1 | 5.00 |
| CHEMBL1950554 | BINODENOSON | 3.0 | 1 | 4.32 |
| CHEMBL3260724 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285819 | — | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL464859 | NECA | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3350613 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL1950649 | APADENOSON | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL331372 | CGS-21680 | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL186113 | GW-328267 | Ki | = | 369.0 | nM | 6.43 |
| CHEMBL317052 | REGADENOSON ANHYDROUS | Ki | = | 3770.0 | nM | 5.42 |
| CHEMBL1950553 | SONEDENOSON | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1950554 | BINODENOSON | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL3260724 | — | Ki | - | — | - |