Assay Detail
Binding
CHEMBL3267357
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Inhibition of rat recombinant adenosine A1 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Adenosine A2A receptor as a drug discovery target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.23 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | — | 1 | 8.46 |
| CHEMBL183181 | — | — | 1 | 7.39 |
| CHEMBL184309 | — | — | 1 | 6.09 |
| CHEMBL413079 | — | — | 1 | 6.05 |
| CHEMBL426738 | — | — | 1 | 5.97 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.07 |
| CHEMBL25964 | — | — | 1 | 4.55 |
| CHEMBL174628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL183181 | — | Ki | = | 40.8 | nM | 7.39 |
| CHEMBL184309 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL413079 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL426738 | — | Ki | = | 1071.0 | nM | 5.97 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL25964 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL174628 | — | Ki | > | 250.0 | nM | - |