Assay Detail
Functional
CHEMBL3267429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H1993 cells after 48 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1993 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.04 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3263959 | — | — | 1 | 8.70 |
| CHEMBL3263958 | — | — | 1 | 8.30 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.21 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 5.96 |
| CHEMBL3263964 | — | — | 1 | 5.87 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.69 |
| CHEMBL3263963 | — | — | 1 | 5.57 |
| CHEMBL3263965 | — | — | 1 | 5.40 |
| CHEMBL3263968 | — | — | 1 | 5.39 |
| CHEMBL3263966 | — | — | 1 | 5.36 |
| CHEMBL3263960 | — | — | 1 | 5.35 |
| CHEMBL3263967 | — | — | 1 | 5.30 |
| CHEMBL3263961 | — | — | 1 | 5.28 |
| CHEMBL3263962 | — | — | 1 | 5.21 |
| CHEMBL3263969 | — | — | 1 | - |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | - |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3263959 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3263958 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 1108.0 | nM | 5.96 |
| CHEMBL3263964 | — | IC50 | = | 1359.0 | nM | 5.87 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 2043.0 | nM | 5.69 |
| CHEMBL3263963 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL3263965 | — | IC50 | = | 4001.0 | nM | 5.40 |
| CHEMBL3263968 | — | IC50 | = | 4028.0 | nM | 5.39 |
| CHEMBL3263966 | — | IC50 | = | 4328.0 | nM | 5.36 |
| CHEMBL3263960 | — | IC50 | = | 4458.0 | nM | 5.35 |
| CHEMBL3263967 | — | IC50 | = | 5035.0 | nM | 5.30 |
| CHEMBL3263961 | — | IC50 | = | 5226.0 | nM | 5.28 |
| CHEMBL3263962 | — | IC50 | = | 6241.0 | nM | 5.21 |
| CHEMBL3263969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1091644 | LINSITINIB | IC50 | - | — | - | |
| CHEMBL1173655 | AFATINIB | IC50 | > | 12500.0 | nM | - |