Assay Detail
ADMET
CHEMBL3267480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HL-7702 cells after 48 hrs by MTT assay
22
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.55 | 4.88 |
| Activity | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | — | 2 | 4.88 |
| CHEMBL3264619 | — | — | 2 | 4.83 |
| CHEMBL3264612 | — | — | 2 | 4.73 |
| CHEMBL3264615 | — | — | 2 | 4.70 |
| CHEMBL3264617 | — | — | 2 | 4.68 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 2 | 4.61 |
| CHEMBL3264613 | — | — | 2 | 4.42 |
| CHEMBL3264614 | — | — | 2 | 4.38 |
| CHEMBL3264618 | — | — | 2 | 4.29 |
| CHEMBL3264611 | — | — | 2 | 4.28 |
| CHEMBL3264616 | — | — | 2 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | IC50 | = | 13040.0 | nM | 4.88 |
| CHEMBL3264619 | — | IC50 | = | 14820.0 | nM | 4.83 |
| CHEMBL3264612 | — | IC50 | = | 18630.0 | nM | 4.73 |
| CHEMBL3264615 | — | IC50 | = | 20090.0 | nM | 4.70 |
| CHEMBL3264617 | — | IC50 | = | 20680.0 | nM | 4.68 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 24610.0 | nM | 4.61 |
| CHEMBL3264613 | — | IC50 | = | 38010.0 | nM | 4.42 |
| CHEMBL3264614 | — | IC50 | = | 41770.0 | nM | 4.38 |
| CHEMBL3264618 | — | IC50 | = | 50820.0 | nM | 4.29 |
| CHEMBL3264611 | — | IC50 | = | 52430.0 | nM | 4.28 |
| CHEMBL3264616 | — | IC50 | = | 53630.0 | nM | 4.27 |
| CHEMBL3264611 | — | Activity | - | — | - | |
| CHEMBL3264612 | — | Activity | - | — | - | |
| CHEMBL3264613 | — | Activity | - | — | - | |
| CHEMBL3264614 | — | Activity | - | — | - | |
| CHEMBL3264615 | — | Activity | - | — | - | |
| CHEMBL3264616 | — | Activity | - | — | - | |
| CHEMBL3264617 | — | Activity | - | — | - | |
| CHEMBL3264618 | — | Activity | - | — | - | |
| CHEMBL3264619 | — | Activity | - | — | - | |
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | Activity | - | — | - | |
| CHEMBL44657 | ETOPOSIDE | Activity | - | — | - |