Assay Detail
Binding
CHEMBL3267499
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Inhibition of AChE in bovine erythrocytes using acetylthiocholine iodide as substrate by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.15 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217012 | — | — | 1 | 6.40 |
| CHEMBL3263347 | — | — | 1 | 5.89 |
| CHEMBL3263349 | — | — | 1 | 5.75 |
| CHEMBL3263351 | — | — | 1 | 5.43 |
| CHEMBL2177716 | — | — | 1 | 5.25 |
| CHEMBL2181475 | — | — | 1 | 5.13 |
| CHEMBL3263348 | — | — | 1 | 4.67 |
| CHEMBL3263350 | — | — | 1 | 4.44 |
| CHEMBL3263352 | — | — | 1 | 4.32 |
| CHEMBL2177708 | — | — | 1 | 4.26 |
| CHEMBL2177718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217012 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3263347 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3263349 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3263351 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2177716 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2181475 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3263348 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL3263350 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3263352 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL2177708 | — | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL2177718 | — | IC50 | = | 377000.0 | nM | - |