Assay Detail
Functional
CHEMBL3267609
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Antiplatelet activity in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation in presence of 10 uM ADP
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.70 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3263056 | — | — | 1 | 6.89 |
| CHEMBL3263066 | — | — | 1 | 6.35 |
| CHEMBL3263069 | — | — | 1 | 6.08 |
| CHEMBL3263067 | — | — | 1 | 6.06 |
| CHEMBL3263071 | — | — | 1 | 6.05 |
| CHEMBL3263076 | — | — | 1 | 6.05 |
| CHEMBL3263075 | — | — | 1 | 6.03 |
| CHEMBL3263057 | — | — | 1 | 6.00 |
| CHEMBL3263068 | — | — | 1 | 5.92 |
| CHEMBL3263074 | — | — | 1 | 5.89 |
| CHEMBL3263070 | — | — | 1 | 5.80 |
| CHEMBL3263073 | — | — | 1 | 5.58 |
| CHEMBL3263062 | — | — | 1 | 5.43 |
| CHEMBL3263058 | — | — | 1 | 5.27 |
| CHEMBL3263060 | — | — | 1 | 5.05 |
| CHEMBL3263072 | — | — | 1 | 4.96 |
| CHEMBL2333770 | — | — | 1 | 4.96 |
| CHEMBL2401864 | — | — | 1 | 4.24 |
| CHEMBL3263065 | — | — | 1 | - |
| CHEMBL3263064 | — | — | 1 | - |
| CHEMBL3263063 | — | — | 1 | - |
| CHEMBL3263061 | — | — | 1 | - |
| CHEMBL3263059 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3263056 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3263066 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3263069 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3263067 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3263071 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3263076 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3263075 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3263057 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3263068 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3263074 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3263070 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3263073 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3263062 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3263058 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3263060 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3263072 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2333770 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2401864 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL3263065 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3263064 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3263063 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3263061 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3263059 | — | IC50 | > | 10000.0 | nM | - |