Assay Detail
Binding
CHEMBL3268019
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Inhibition of c-Met (unknown origin) using poly Glu:Tyr (4:1) as substrate after 60 mins by ELISA
22
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel type II c-Met inhibitors based on BMS-777607.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.27 | 9.15 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260966 | — | — | 1 | 9.15 |
| CHEMBL3260967 | — | — | 1 | 9.05 |
| CHEMBL3260968 | — | — | 1 | 8.77 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.43 |
| CHEMBL3260962 | — | — | 1 | 7.70 |
| CHEMBL3260964 | — | — | 1 | 7.57 |
| CHEMBL3091589 | — | — | 1 | 7.41 |
| CHEMBL3260965 | — | — | 1 | 7.30 |
| CHEMBL3260953 | — | — | 1 | 7.15 |
| CHEMBL3260961 | — | — | 1 | 7.09 |
| CHEMBL3260954 | — | — | 1 | 7.00 |
| CHEMBL3260952 | — | — | 1 | 6.78 |
| CHEMBL3260951 | — | — | 1 | 6.77 |
| CHEMBL3260948 | — | — | 1 | 6.54 |
| CHEMBL3260950 | — | — | 1 | 6.43 |
| CHEMBL3260960 | — | — | 1 | 6.37 |
| CHEMBL3260956 | — | — | 1 | 6.36 |
| CHEMBL3260949 | — | — | 1 | 6.31 |
| CHEMBL3260955 | — | — | 1 | 5.98 |
| CHEMBL3260959 | — | — | 1 | - |
| CHEMBL3260958 | — | — | 1 | - |
| CHEMBL3260957 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260966 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3260967 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3260968 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3260962 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3260964 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL3091589 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3260965 | — | IC50 | = | 49.6 | nM | 7.30 |
| CHEMBL3260953 | — | IC50 | = | 70.2 | nM | 7.15 |
| CHEMBL3260961 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3260954 | — | IC50 | = | 100.8 | nM | 7.00 |
| CHEMBL3260952 | — | IC50 | = | 165.5 | nM | 6.78 |
| CHEMBL3260951 | — | IC50 | = | 168.7 | nM | 6.77 |
| CHEMBL3260948 | — | IC50 | = | 290.5 | nM | 6.54 |
| CHEMBL3260950 | — | IC50 | = | 373.2 | nM | 6.43 |
| CHEMBL3260960 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL3260956 | — | IC50 | = | 432.9 | nM | 6.36 |
| CHEMBL3260949 | — | IC50 | = | 494.7 | nM | 6.31 |
| CHEMBL3260955 | — | IC50 | = | 1044.0 | nM | 5.98 |
| CHEMBL3260959 | — | Inhibition | - | % | - | |
| CHEMBL3260958 | — | IC50 | - | — | - | |
| CHEMBL3260957 | — | Inhibition | - | % | - |