Assay Detail
Functional
CHEMBL3268024
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Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel type II c-Met inhibitors based on BMS-777607.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.06 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260967 | — | — | 1 | 7.40 |
| CHEMBL3260968 | — | — | 1 | 7.24 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260967 | — | IC50 | = | 39.7 | nM | 7.40 |
| CHEMBL3260968 | — | IC50 | = | 57.7 | nM | 7.24 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 285.8 | nM | 6.54 |