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Assay Detail

CHEMBL3268300

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.
Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid T, Guedes RC, dos Santos DJ, Rosenthal PJ, Moreira R.
Eur J Med Chem (2014) 80 : 523 -534
PubMed 24813880 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 5.43 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 6.85
CHEMBL580847 1 5.93
CHEMBL3262107 1 5.64
CHEMBL3262109 1 5.59
CHEMBL3262121 1 5.52
CHEMBL2177353 1 5.49
CHEMBL3262123 1 5.48
CHEMBL3262124 1 5.46
CHEMBL3262098 1 5.43
CHEMBL3262122 1 5.40
CHEMBL3262104 1 5.36
CHEMBL2253272 1 5.33
CHEMBL3262108 1 5.32
CHEMBL3262112 1 5.32
CHEMBL3262100 1 5.30
CHEMBL3262103 1 5.28
CHEMBL3262117 1 5.23
CHEMBL3262097 1 5.18
CHEMBL3262096 1 5.13
CHEMBL1946826 1 5.10
CHEMBL3262099 1 5.07
CHEMBL3262118 1 5.00
CHEMBL3262120 1 -
CHEMBL3262119 1 -
CHEMBL1946828 1 -
CHEMBL3262116 1 -
CHEMBL3262115 1 -
CHEMBL3262114 1 -
CHEMBL383812 1 -
CHEMBL3262113 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 140.0 nM 6.85
CHEMBL580847 IC50 = 1180.0 nM 5.93
CHEMBL3262107 IC50 = 2310.0 nM 5.64
CHEMBL3262109 IC50 = 2560.0 nM 5.59
CHEMBL3262121 IC50 = 3030.0 nM 5.52
CHEMBL2177353 IC50 = 3210.0 nM 5.49
CHEMBL3262123 IC50 = 3340.0 nM 5.48
CHEMBL3262124 IC50 = 3470.0 nM 5.46
CHEMBL3262098 IC50 = 3700.0 nM 5.43
CHEMBL3262122 IC50 = 4010.0 nM 5.40
CHEMBL3262104 IC50 = 4410.0 nM 5.36
CHEMBL2253272 IC50 = 4700.0 nM 5.33
CHEMBL3262108 IC50 = 4780.0 nM 5.32
CHEMBL3262112 IC50 = 4800.0 nM 5.32
CHEMBL3262100 IC50 = 5000.0 nM 5.30
CHEMBL3262103 IC50 = 5210.0 nM 5.28
CHEMBL3262117 IC50 = 5840.0 nM 5.23
CHEMBL3262097 IC50 = 6590.0 nM 5.18
CHEMBL3262096 IC50 = 7340.0 nM 5.13
CHEMBL1946826 IC50 = 7990.0 nM 5.10
CHEMBL3262099 IC50 = 8590.0 nM 5.07
CHEMBL3262118 IC50 = 9880.0 nM 5.00
CHEMBL1315175 (Z)-AURONE IC50 > 10000.0 nM -
CHEMBL3261868 IC50 > 10000.0 nM -
CHEMBL3261869 IC50 > 10000.0 nM -
CHEMBL3261870 IC50 > 10000.0 nM -
CHEMBL2253277 IC50 > 10000.0 nM -
CHEMBL3261871 IC50 > 10000.0 nM -
CHEMBL3261872 IC50 > 10000.0 nM -
CHEMBL3262094 IC50 > 10000.0 nM -
CHEMBL3262095 IC50 > 10000.0 nM -
CHEMBL3262101 IC50 > 10000.0 nM -
CHEMBL3262102 IC50 > 10000.0 nM -
CHEMBL3262105 IC50 > 10000.0 nM -
CHEMBL3262106 IC50 > 10000.0 nM -
CHEMBL3262110 IC50 > 10000.0 nM -
CHEMBL3262111 IC50 > 10000.0 nM -
CHEMBL3262113 IC50 > 10000.0 nM -
CHEMBL383812 IC50 > 10000.0 nM -
CHEMBL3262114 IC50 > 10000.0 nM -
CHEMBL3262115 IC50 > 10000.0 nM -
CHEMBL3262116 IC50 > 10000.0 nM -
CHEMBL1946828 IC50 > 10000.0 nM -
CHEMBL3262119 IC50 > 10000.0 nM -
CHEMBL3262120 IC50 > 10000.0 nM -