Compound Detail
CHEMBL3262107
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3262107 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MAZQVFPYPZZDSX-QNGOZBTKSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
312.4
MW (Da)
4.89
ALogP
2
HBA
0
HBD
26.3
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.64
EC50 1 meas. best 4.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 5.64 | 5.64 | 2310.0 | 1 |
| Neutrophil elastase CHEMBL248 | IC50 | 5.54 | 5.54 | 2900.0 | 1 |
| HEK-293T CHEMBL3706568 | EC50 | 4.15 | 4.15 | 71000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 2310.0 | nM | 5.64 | Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falc... | 24813880 |
| Neutrophil elastase | IC50 | = | 2900.0 | nM | 5.54 | Inhibition of human neutrophil elastase pre-incubated for 30 mins before MeO-Suc... | - |
| HEK-293T | EC50 | = | 71000.0 | nM | 4.15 | Cytotoxicity against HEK293T cells after 48 hrs by MTT assay | 24813880 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24813880 | 10.1016/j.ejmech.2014.04.076 | Unchecked | 2 |
| - | 10.1039/C5MD00164A | Neutrophil elastase | 2 |
| 24813880 | 10.1016/j.ejmech.2014.04.076 | Plasmodium falciparum | 1 |
| 24813880 | 10.1016/j.ejmech.2014.04.076 | HEK-293T | 1 |
| - | 10.1039/C5MD00164A | HEK293 | 1 |
| - | 10.1039/C5MD00164A | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine