Assay Detail
ADMET
CHEMBL3268301
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Cytotoxicity against HEK293T cells after 48 hrs by MTT assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 45 | 4.24 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262118 | — | — | 1 | 4.92 |
| CHEMBL3261870 | — | — | 1 | 4.17 |
| CHEMBL3262107 | — | — | 1 | 4.15 |
| CHEMBL3262109 | — | — | 1 | 4.10 |
| CHEMBL3262096 | — | — | 1 | 4.06 |
| CHEMBL3262117 | — | — | 1 | 4.02 |
| CHEMBL1946828 | — | — | 1 | - |
| CHEMBL2253272 | — | — | 1 | - |
| CHEMBL3262119 | — | — | 1 | - |
| CHEMBL3262120 | — | — | 1 | - |
| CHEMBL3262121 | — | — | 1 | - |
| CHEMBL3262122 | — | — | 1 | - |
| CHEMBL580847 | — | — | 1 | - |
| CHEMBL3262123 | — | — | 1 | - |
| CHEMBL3261872 | — | — | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL1315175 | (Z)-AURONE | — | 1 | - |
| CHEMBL3261868 | — | — | 1 | - |
| CHEMBL3262116 | — | — | 1 | - |
| CHEMBL3262115 | — | — | 1 | - |
| CHEMBL3262114 | — | — | 1 | - |
| CHEMBL383812 | — | — | 1 | - |
| CHEMBL3262113 | — | — | 1 | - |
| CHEMBL3262112 | — | — | 1 | - |
| CHEMBL3262111 | — | — | 1 | - |
| CHEMBL3262110 | — | — | 1 | - |
| CHEMBL3262108 | — | — | 1 | - |
| CHEMBL3262106 | — | — | 1 | - |
| CHEMBL3262124 | — | — | 1 | - |
| CHEMBL3262105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262118 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3261870 | — | EC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3262107 | — | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL3262109 | — | EC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL3262096 | — | EC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL3262117 | — | EC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL76 | CHLOROQUINE | EC50 | - | — | - | |
| CHEMBL3262103 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1315175 | (Z)-AURONE | EC50 | > | 100000.0 | nM | - |
| CHEMBL3261868 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2253272 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2177353 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3261869 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2253277 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1946826 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3261871 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262104 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262094 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262095 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262097 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262098 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262099 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262100 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262101 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262102 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262114 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262105 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262124 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262106 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262108 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262110 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262111 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262112 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262113 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL383812 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3261872 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262115 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262116 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1946828 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262119 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262120 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262121 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262122 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL580847 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3262123 | — | EC50 | > | 100000.0 | nM | - |