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Assay Detail

CHEMBL3757813

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human neutrophil elastase pre-incubated for 30 mins before MeO-Suc-Ala-Ala-Pro-Val-AMC substrate addition by fluorometric assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neutrophil elastase (CHEMBL248)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of C-shaped aurone human neutrophil elastase inhibitors
Lucas SD, Carrasco MP, Goncalves LM, Moreira R, Guedes RC
Medchemcomm (2015) 6 : 1508 -1512
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.80 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3262105 1 6.30
CHEMBL3262102 1 6.30
CHEMBL3262100 1 6.05
CHEMBL3262106 1 5.96
CHEMBL3262099 1 5.85
CHEMBL3262118 1 5.82
CHEMBL3262107 1 5.54
CHEMBL1946826 1 5.54
CHEMBL3262096 1 5.36
CHEMBL1946828 1 5.29
CHEMBL3262094 1 -
CHEMBL3262095 1 -
CHEMBL3262097 1 -
CHEMBL3262098 1 -
CHEMBL3262101 1 -
CHEMBL3262103 1 -
CHEMBL3752247 1 -
CHEMBL3262110 1 -
CHEMBL3261872 1 -
CHEMBL2253272 1 -
CHEMBL2177353 1 -
CHEMBL3261871 1 -
CHEMBL3262117 1 -
CHEMBL3261868 1 -
CHEMBL383812 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3262105 IC50 = 500.0 nM 6.30
CHEMBL3262102 IC50 = 500.0 nM 6.30
CHEMBL3262100 IC50 = 900.0 nM 6.05
CHEMBL3262106 IC50 = 1100.0 nM 5.96
CHEMBL3262099 IC50 = 1400.0 nM 5.85
CHEMBL3262118 IC50 = 1500.0 nM 5.82
CHEMBL3262107 IC50 = 2900.0 nM 5.54
CHEMBL1946826 IC50 = 2900.0 nM 5.54
CHEMBL3262096 IC50 = 4400.0 nM 5.36
CHEMBL1946828 IC50 = 5100.0 nM 5.29
CHEMBL3262094 IC50 - -
CHEMBL3262095 IC50 - -
CHEMBL3262097 IC50 - -
CHEMBL3262098 IC50 - -
CHEMBL3262101 IC50 > 10000.0 nM -
CHEMBL3262103 IC50 - -
CHEMBL3752247 IC50 - -
CHEMBL3262110 IC50 - -
CHEMBL3261872 IC50 - -
CHEMBL2253272 IC50 > 10000.0 nM -
CHEMBL2177353 IC50 - -
CHEMBL3261871 IC50 - -
CHEMBL3262117 IC50 - -
CHEMBL3261868 IC50 - -
CHEMBL383812 IC50 - -