Assay Detail
Binding
CHEMBL3268869
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Binding affinity to sarin-inhibited hemoglobin free human erythrocyte ghost acetylcholinesterase using acetylthiocholineiodide as substrate measured up to 1 hr by Ellman method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 4.49 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261992 | — | — | 1 | 5.07 |
| CHEMBL3261990 | — | — | 1 | 4.68 |
| CHEMBL291233 | OBIDOXIME CHLORIDE | 2.0 | 1 | 4.67 |
| CHEMBL3261988 | — | — | 1 | 4.61 |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | 4.59 |
| CHEMBL3261987 | — | — | 1 | 4.52 |
| CHEMBL3261984 | — | — | 1 | 4.37 |
| CHEMBL3261991 | — | — | 1 | 4.32 |
| CHEMBL3261986 | — | — | 1 | 4.28 |
| CHEMBL3261985 | — | — | 1 | 4.24 |
| CHEMBL3261989 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261992 | — | Kd | = | 8550.0 | nM | 5.07 |
| CHEMBL3261990 | — | Kd | = | 20820.0 | nM | 4.68 |
| CHEMBL291233 | OBIDOXIME CHLORIDE | Kd | = | 21480.0 | nM | 4.67 |
| CHEMBL3261988 | — | Kd | = | 24390.0 | nM | 4.61 |
| CHEMBL748 | PRALIDOXIME CHLORIDE | Kd | = | 25720.0 | nM | 4.59 |
| CHEMBL3261987 | — | Kd | = | 30230.0 | nM | 4.52 |
| CHEMBL3261984 | — | Kd | = | 42860.0 | nM | 4.37 |
| CHEMBL3261991 | — | Kd | = | 48380.0 | nM | 4.32 |
| CHEMBL3261986 | — | Kd | = | 52320.0 | nM | 4.28 |
| CHEMBL3261985 | — | Kd | = | 57960.0 | nM | 4.24 |
| CHEMBL3261989 | — | Kd | = | 84290.0 | nM | 4.07 |