Assay Detail
Functional
CHEMBL3268907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anthelmintic activity against sexually mature Schistosoma mansoni PR-1 adult worm assessed as parasite death incubated for overnight measured after 7 days drug wash-out period by stereomicroscopic analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Schistosoma mansoni |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.12 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1235551 | PRAZIQUANTEL, (R)- | 3.0 | 1 | 6.30 |
| CHEMBL976 | PRAZIQUANTEL | 4.0 | 1 | 5.80 |
| CHEMBL3264246 | — | — | 1 | 4.27 |
| CHEMBL3264245 | — | — | 1 | 4.11 |
| CHEMBL3264247 | — | — | 1 | - |
| CHEMBL3264248 | — | — | 1 | - |
| CHEMBL3264249 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1235551 | PRAZIQUANTEL, (R)- | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL976 | PRAZIQUANTEL | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3264246 | — | EC50 | = | 53300.0 | nM | 4.27 |
| CHEMBL3264245 | — | EC50 | = | 78100.0 | nM | 4.11 |
| CHEMBL3264247 | — | EC50 | - | — | - | |
| CHEMBL3264248 | — | EC50 | = | 132100.0 | nM | - |
| CHEMBL3264249 | — | EC50 | > | 300000.0 | nM | - |