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Compound Detail

CHEMBL1235551

PRAZIQUANTEL, (R)-
🧪 Phase III
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🧪 Phase III
O=C(C1CCCCC1)N1CC(=O)N2CCc3ccccc3[C@@H]2C1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1235551
Name PRAZIQUANTEL, (R)-
Phase Phase III
Structure Type MOL
InChI Key FSVJFNAIGNNGKK-KRWDZBQOSA-N

Known Names

(-)-praziquantel (r)-(-)-praziquantel (r)-praziquantel Arprazicuantel Arpraziquantel L-praziquantel L-pzq MSC-2499550A Msc2499550a Praziquantel, (-)- Praziquantel, (r)-
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
11
Known Names
2
Indications

Molecular Properties

312.4
MW (Da)
2.53
ALogP
2
HBA
0
HBD
40.6
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Flags

Natural Product

Extended Properties

Molecular Formula C19H24N2O2
MW 312.41
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness -0.81

Indications

Helminthiasis Schistosomiasis

ATC Classification

P02BA03
arpraziquantel
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTHELMINTICS

Activity Summary

EC50 4 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 EC50 7.3 6.9833 50.0 3
Schistosoma mansoni
CHEMBL612893
 EC50 6.3 6.3 500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 50.0 nM 7.3 Activation of Echinococcus granulosus in TRPM binding site of PZQ expressed in H... 37970586
Unchecked EC50 = 80.0 nM 7.1 Activation of Mesocestoides corti in TRPM binding site of PZQ expressed in HEK29... 37970586
Unchecked EC50 = 280.0 nM 6.55 Activation of Schistosoma mansoni in TRPM binding site of PZQ expressed in HEK29... 37970586
Schistosoma mansoni EC50 = 500.0 nM 6.3 Anthelmintic activity against sexually mature Schistosoma mansoni PR-1 adult wor... 24775301

Literature References

PubMed DOI Target Context # Activities
37970586 10.1021/acsmedchemlett.3c00350 Unchecked 3
24775301 10.1016/j.bmcl.2014.04.014 Schistosoma mansoni 2
37970586 10.1021/acsmedchemlett.3c00350 Schistosoma mansoni 2
- 10.6019/CHEMBL5441142 Schistosoma mansoni 2
37970586 10.1021/acsmedchemlett.3c00350 Rodentolepis nana 1

Data from ChEMBL 36 via Core Engine