Assay Detail
Binding
CHEMBL3268962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.66 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289233 | IODOMELATONIN | — | 1 | 10.17 |
| CHEMBL3260979 | — | — | 1 | 8.87 |
| CHEMBL34730 | — | — | 1 | 7.94 |
| CHEMBL339105 | — | — | 1 | 7.49 |
| CHEMBL3260983 | — | — | 1 | 7.04 |
| CHEMBL286615 | LUZINDOLE | — | 1 | 6.80 |
| CHEMBL124699 | — | — | 1 | 6.68 |
| CHEMBL285718 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289233 | IODOMELATONIN | Ki | = | 0.068 | nM | 10.17 |
| CHEMBL3260979 | — | Ki | = | 1.34 | nM | 8.87 |
| CHEMBL34730 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL339105 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL3260983 | — | Ki | = | 90.4 | nM | 7.04 |
| CHEMBL286615 | LUZINDOLE | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL124699 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL285718 | — | Ki | = | 501.0 | nM | 6.30 |