Melatonin receptor type 1A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P48039. Use UniProt P48039 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P48039 as the stable identity anchor, then attach disease evidence before program review.
Melatonin receptor type 1A
Review this target as Melatonin receptor type 1A, mapped to UniProt P48039. Sequence length is 350 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Melatonin receptor type 1A as ChEMBL target CHEMBL1945, mapped to UniProt P48039. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Melatonin receptor type 1A is the right protein anchor across sources, using UniProt P48039 as the stable mapping.
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| Preferred Name | Melatonin receptor type 1A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P48039 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Melatonin receptor type 1A |
| UniProt Accession | P48039 |
| Component Type | Protein |
| Sequence Length | 350 aa |
Melatonin receptor type 1A
Review this target as Melatonin receptor type 1A, mapped to UniProt P48039. Sequence length is 350 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL132802 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL330137 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL287560 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL1774529 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL336054 | 10.92 | Ki | 0.012 | Preclinical |
| CHEMBL139855 | 10.9 | IC50 | 0.01259 | Preclinical |
| CHEMBL1774514 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL289233 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL1218 | 10.86 | Ki | 0.0138 | Approved |
| CHEMBL3648356 | 10.82 | EC50 | 0.015 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 114 | 798 | 7.8 |
| single protein format | 97 | 128 | 8.1 |
| cell membrane format | 8 | 39 | 7.9 |
| assay format | 5 | 155 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 82 | 153 | 8.1 |
| assay format | 13 | 8 | 7.0 |
| cell membrane format | 2 | 6 | 6.6 |