Assay Detail
Binding
CHEMBL3268963
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.00 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34730 | — | — | 1 | 9.70 |
| CHEMBL289233 | IODOMELATONIN | — | 1 | 9.66 |
| CHEMBL339105 | — | — | 1 | 9.60 |
| CHEMBL3260983 | — | — | 1 | 9.10 |
| CHEMBL285718 | — | — | 1 | 8.82 |
| CHEMBL3260979 | — | — | 1 | 8.66 |
| CHEMBL124699 | — | — | 1 | 8.46 |
| CHEMBL286615 | LUZINDOLE | — | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34730 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL289233 | IODOMELATONIN | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL339105 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL3260983 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL285718 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3260979 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL124699 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL286615 | LUZINDOLE | Ki | = | 10.2 | nM | 7.99 |