Melatonin receptor type 1B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P49286. Use UniProt P49286 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49286 as the stable identity anchor, then attach disease evidence before program review.
Melatonin receptor type 1B
Review this target as Melatonin receptor type 1B, mapped to UniProt P49286. Sequence length is 362 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Melatonin receptor type 1B as ChEMBL target CHEMBL1946, mapped to UniProt P49286. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Melatonin receptor type 1B is the right protein anchor across sources, using UniProt P49286 as the stable mapping.
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| Preferred Name | Melatonin receptor type 1B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P49286 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Melatonin receptor type 1B |
| UniProt Accession | P49286 |
| Component Type | Protein |
| Sequence Length | 362 aa |
Melatonin receptor type 1B
Review this target as Melatonin receptor type 1B, mapped to UniProt P49286. Sequence length is 362 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5555481 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL1774516 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL314512 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL1774529 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL1774514 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL1774519 | 10.92 | Ki | 0.012 | Preclinical |
| CHEMBL1774521 | 10.85 | Ki | 0.014 | Preclinical |
| CHEMBL285718 | 10.8 | Ki | 0.01585 | Preclinical |
| CHEMBL1774513 | 10.74 | Ki | 0.018 | Preclinical |
| CHEMBL287560 | 10.7 | Ki | 0.02 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 102 | 801 | 8.2 |
| single protein format | 35 | 170 | 8.2 |
| cell membrane format | 8 | 38 | 8.1 |
| assay format | 1 | 6 | 8.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 82 | 156 | 8.5 |
| assay format | 7 | 9 | 7.9 |
| cell membrane format | 2 | 11 | 6.8 |