Assay Detail
Binding
CHEMBL3269024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli N-terminal strep-tagged MenA expressed in Escherichia coli C43 (DE3) assessed as demethylmenaquinone-3 formation after 30 mins by HPLC analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Multitarget drug discovery for tuberculosis and other infectious diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.54 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261880 | — | — | 1 | 6.40 |
| CHEMBL3261884 | — | — | 1 | 6.00 |
| CHEMBL3261881 | — | — | 1 | 5.75 |
| CHEMBL3261883 | — | — | 1 | 5.72 |
| CHEMBL3261890 | — | — | 1 | 5.50 |
| CHEMBL561057 | SQ109 | 2.0 | 1 | 5.48 |
| CHEMBL3261889 | — | — | 1 | 5.48 |
| CHEMBL3261882 | — | — | 1 | 5.38 |
| CHEMBL3261887 | — | — | 1 | 5.34 |
| CHEMBL3261888 | — | — | 1 | 5.34 |
| CHEMBL3261885 | — | — | 1 | 5.24 |
| CHEMBL3261886 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261880 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3261884 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3261881 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3261883 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3261890 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL561057 | SQ109 | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3261889 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3261882 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3261887 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3261888 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3261885 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3261886 | — | IC50 | = | 16000.0 | nM | 4.80 |