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Compound Detail

CHEMBL3261889

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CC(C)=CCC/C(C)=C/CNCCOc1cccc2ccccc12

Basic Information

ChEMBL ID CHEMBL3261889
Phase Preclinical
Structure Type MOL
InChI Key SZJSFYALLNAAAA-XMHGGMMESA-N
6
Targets
10
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

323.5
MW (Da)
5.50
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.49
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H29NO
MW 323.48
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness 0.51

Activity Summary

IC50 10 meas. best 5.48

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.48 5.48 3300.0 1
Escherichia coli
CHEMBL354
IC50 5.15 4.745 7100.0 2
Bacillus subtilis
CHEMBL359
IC50 5.13 5.13 7400.0 1
Saccharomyces cerevisiae
CHEMBL361
IC50 4.96 4.96 11000.0 1
MCF7
CHEMBL387
IC50 4.66 4.66 22000.0 1
Candida albicans
CHEMBL366
IC50 4.43 4.43 37000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24568559 10.1021/jm500131s Mycolicibacterium smegmatis 3
24568559 10.1021/jm500131s Unchecked 3
24568559 10.1021/jm500131s Escherichia coli 2
24568559 10.1021/jm500131s Mycobacterium tuberculosis 1
24568559 10.1021/jm500131s Staphylococcus aureus 1
24568559 10.1021/jm500131s Bacillus subtilis 1
24568559 10.1021/jm500131s Saccharomyces cerevisiae 1
24568559 10.1021/jm500131s Candida albicans 1
24568559 10.1021/jm500131s Plasmodium falciparum 1
24568559 10.1021/jm500131s MCF7 1

Data from ChEMBL 36 via Core Engine