Assay Detail
Binding
CHEMBL3269288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM3 kinase (unknown origin) using 5-FAM-labeled BAD peptide as substrate after 90 mins by fluorescence polarization assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-3 (CHEMBL5407) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.67 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3264257 | — | — | 1 | 8.19 |
| CHEMBL3264261 | — | — | 1 | 8.11 |
| CHEMBL3264258 | — | — | 1 | 8.00 |
| CHEMBL3264255 | — | — | 1 | 7.69 |
| CHEMBL3264253 | — | — | 1 | 7.66 |
| CHEMBL3264254 | — | — | 1 | 7.52 |
| CHEMBL3264260 | — | — | 1 | 7.52 |
| CHEMBL3264259 | — | — | 1 | 7.50 |
| CHEMBL3264252 | — | — | 1 | 7.29 |
| CHEMBL3264256 | — | — | 1 | 7.25 |
| CHEMBL44541 | MERIDIANIN C | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3264257 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3264261 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3264258 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL3264255 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL3264253 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL3264254 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3264260 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL3264259 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL3264252 | — | IC50 | = | 50.9 | nM | 7.29 |
| CHEMBL3264256 | — | IC50 | = | 55.7 | nM | 7.25 |
| CHEMBL44541 | MERIDIANIN C | IC50 | - | — | - |