Assay Detail
Functional
CHEMBL3269357
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Antiasthamic activity in Wistar rat tracheal ring assessed as reversal of carbachol-induced contraction
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Semisynthesis, ex vivo evaluation, and SAR studies of coumarin derivatives as potential antiasthmatic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 4.16 | 4.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262897 | — | — | 1 | 4.38 |
| CHEMBL325864 | SCOPARONE | — | 1 | 4.10 |
| CHEMBL1982193 | — | — | 1 | 4.10 |
| CHEMBL3262898 | — | — | 1 | 4.05 |
| CHEMBL3262899 | — | — | 1 | - |
| CHEMBL3262900 | — | — | 1 | - |
| CHEMBL3262901 | — | — | 1 | - |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | - |
| CHEMBL49732 | HERNIARIN | — | 1 | - |
| CHEMBL191528 | ETHOXYCOUMARIN | — | 1 | - |
| CHEMBL568516 | 7-PROPOXYCOUMARIN | — | 1 | - |
| CHEMBL487711 | 7-ACETOXYCOUMARIN | — | 1 | - |
| CHEMBL1538522 | — | — | 1 | - |
| CHEMBL2273031 | — | — | 1 | - |
| CHEMBL12208 | HYMECROMONE | 2.0 | 1 | - |
| CHEMBL12636 | HYMECROMONE METHYL ETHER | — | 1 | - |
| CHEMBL3262902 | — | — | 1 | - |
| CHEMBL12019 | — | — | 1 | - |
| CHEMBL1351920 | — | — | 1 | - |
| CHEMBL1972966 | — | — | 1 | - |
| CHEMBL244743 | ESCULETIN | — | 1 | - |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262897 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL325864 | SCOPARONE | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1982193 | — | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL3262898 | — | EC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL3262899 | — | EC50 | = | 231000.0 | nM | - |
| CHEMBL3262900 | — | EC50 | - | — | - | |
| CHEMBL3262901 | — | EC50 | - | — | - | |
| CHEMBL51628 | UMBELLIFERONE | EC50 | = | 449000.0 | nM | - |
| CHEMBL49732 | HERNIARIN | EC50 | = | 244000.0 | nM | - |
| CHEMBL191528 | ETHOXYCOUMARIN | EC50 | = | 245000.0 | nM | - |
| CHEMBL568516 | 7-PROPOXYCOUMARIN | EC50 | = | 133000.0 | nM | - |
| CHEMBL487711 | 7-ACETOXYCOUMARIN | EC50 | - | — | - | |
| CHEMBL1538522 | — | EC50 | - | — | - | |
| CHEMBL2273031 | — | EC50 | - | — | - | |
| CHEMBL12208 | HYMECROMONE | EC50 | = | 260000.0 | nM | - |
| CHEMBL12636 | HYMECROMONE METHYL ETHER | EC50 | = | 230000.0 | nM | - |
| CHEMBL3262902 | — | EC50 | = | 267000.0 | nM | - |
| CHEMBL12019 | — | EC50 | = | 360000.0 | nM | - |
| CHEMBL1351920 | — | EC50 | - | — | - | |
| CHEMBL1972966 | — | EC50 | = | 200000.0 | nM | - |
| CHEMBL244743 | ESCULETIN | EC50 | - | — | - | |
| CHEMBL1355736 | THEOPHYLLINE | EC50 | = | 144000.0 | nM | - |