Assay Detail
Functional
CHEMBL3269441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human C32 cells harboring R-Raf V600E mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C32 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.29 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3264002 | AVUTOMETINIB | 3.0 | 1 | 7.33 |
| CHEMBL3092195 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3264002 | AVUTOMETINIB | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3092195 | — | IC50 | = | 57.0 | nM | 7.24 |