Assay Detail
Binding
CHEMBL3269587
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Binding affinity to human histamine H3 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.97 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129306 | — | — | 1 | 9.13 |
| CHEMBL129542 | JNJ-5207852 | — | 1 | 9.00 |
| CHEMBL129785 | — | — | 1 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129306 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL129542 | JNJ-5207852 | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL129785 | — | Ki | = | 1.698 | nM | 8.77 |