Assay Detail
Binding
CHEMBL3269751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.48 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334079 | — | — | 1 | 9.20 |
| CHEMBL14453 | — | — | 1 | 8.51 |
| CHEMBL3260984 | — | — | 1 | 8.47 |
| CHEMBL3260985 | — | — | 1 | 8.41 |
| CHEMBL429392 | — | — | 1 | 8.41 |
| CHEMBL1097525 | — | — | 1 | 8.28 |
| CHEMBL3260986 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334079 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL14453 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL3260984 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL3260985 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL429392 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1097525 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL3260986 | — | Ki | = | 7.9 | nM | 8.10 |