Assay Detail
Binding
CHEMBL3270695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as inhibition of pramipexole-stimulated beta-arrestin recruitment
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.19 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540612 | — | — | 1 | 7.89 |
| CHEMBL3265067 | — | — | 1 | 6.49 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540612 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3265067 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL301265 | PRAMIPEXOLE | IC50 | - | — | - |