Assay Detail
Binding
CHEMBL3271121
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Inhibition of BuChE in human serum using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.02 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262667 | — | — | 1 | 5.64 |
| CHEMBL3262666 | — | — | 1 | 5.49 |
| CHEMBL3262661 | — | — | 1 | 5.46 |
| CHEMBL3262665 | — | — | 1 | 5.23 |
| CHEMBL3262663 | — | — | 1 | 5.22 |
| CHEMBL3262664 | — | — | 1 | 5.19 |
| CHEMBL3262673 | — | — | 1 | 5.03 |
| CHEMBL3262669 | — | — | 1 | 4.97 |
| CHEMBL3262662 | — | — | 1 | 4.95 |
| CHEMBL3262671 | — | — | 1 | 4.89 |
| CHEMBL3262670 | — | — | 1 | 4.80 |
| CHEMBL3262658 | — | — | 1 | 4.78 |
| CHEMBL3262672 | — | — | 1 | 4.66 |
| CHEMBL3262668 | — | — | 1 | 4.62 |
| CHEMBL510363 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262667 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL3262666 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL3262661 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL3262665 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL3262663 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL3262664 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL3262673 | — | IC50 | = | 9290.0 | nM | 5.03 |
| CHEMBL3262669 | — | IC50 | = | 10590.0 | nM | 4.97 |
| CHEMBL3262662 | — | IC50 | = | 11170.0 | nM | 4.95 |
| CHEMBL3262671 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL3262670 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL3262658 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL3262672 | — | IC50 | = | 21710.0 | nM | 4.66 |
| CHEMBL3262668 | — | IC50 | = | 23730.0 | nM | 4.62 |
| CHEMBL510363 | — | IC50 | = | 46770.0 | nM | 4.33 |