Assay Detail
Functional
CHEMBL3271226
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiretroviral activity against HIV-1 3B infected in human CEM/0 cells expressing thymidine kinase assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM/0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, anti-HIV and cytostatic evaluation of 3'-deoxy-3'-fluorothymidine (FLT) pro-nucleotides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.83 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105318 | ALOVUDINE | 2.0 | 1 | 8.21 |
| CHEMBL3260474 | — | — | 1 | 7.77 |
| CHEMBL3260470 | — | — | 1 | 7.50 |
| CHEMBL3260473 | — | — | 1 | 7.44 |
| CHEMBL3260469 | — | — | 1 | 7.32 |
| CHEMBL3260118 | — | — | 1 | 7.00 |
| CHEMBL3260471 | — | — | 1 | 6.92 |
| CHEMBL3260464 | — | — | 1 | 6.89 |
| CHEMBL3260466 | — | — | 1 | 6.80 |
| CHEMBL3260120 | — | — | 1 | 6.54 |
| CHEMBL3260465 | — | — | 1 | 6.37 |
| CHEMBL3260117 | — | — | 1 | 6.26 |
| CHEMBL3260467 | — | — | 1 | 6.25 |
| CHEMBL3260472 | — | — | 1 | 6.19 |
| CHEMBL3260119 | — | — | 1 | 6.12 |
| CHEMBL3260468 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105318 | ALOVUDINE | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3260474 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3260470 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3260473 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3260469 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3260118 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3260471 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3260464 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3260466 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3260120 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3260465 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3260117 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3260467 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3260472 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3260119 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3260468 | — | EC50 | = | 2300.0 | nM | 5.64 |