Assay Detail
Binding
CHEMBL3280909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-naloxone from rat opioid receptor after 30 mins by liquid scintillation counting analysis in absence of NaCl
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Analgesics. 1. Synthesis and analgesic properties of N-sec-alkyl- and N-tert-alkylnormorphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.53 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415284 | NALORPHINE | 2.0 | 1 | 8.70 |
| CHEMBL3275470 | — | — | 1 | 8.47 |
| CHEMBL3275472 | — | — | 1 | 8.38 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.00 |
| CHEMBL3275471 | — | — | 1 | 7.85 |
| CHEMBL3275464 | — | — | 1 | 7.80 |
| CHEMBL3275469 | — | — | 1 | 7.72 |
| CHEMBL3275463 | — | — | 1 | 7.57 |
| CHEMBL3275461 | — | — | 1 | 7.55 |
| CHEMBL3275467 | — | — | 1 | 7.47 |
| CHEMBL3275465 | — | — | 1 | 7.43 |
| CHEMBL3272387 | — | — | 1 | 7.42 |
| CHEMBL3275468 | — | — | 1 | 7.29 |
| CHEMBL3275462 | — | — | 1 | 7.22 |
| CHEMBL3275466 | — | — | 1 | 7.11 |
| CHEMBL3275458 | — | — | 1 | 6.00 |
| CHEMBL3275460 | — | — | 1 | 6.00 |
| CHEMBL3275459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415284 | NALORPHINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3275470 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3275472 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL70 | MORPHINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3275471 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3275464 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3275469 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3275463 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3275461 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3275467 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3275465 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3272387 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3275468 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3275462 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3275466 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3275458 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3275460 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3275459 | — | IC50 | > | 1000.0 | nM | - |