Assay Detail
Binding
CHEMBL3280910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-naloxone from rat opioid receptor after 30 mins by liquid scintillation counting analysis in presence of NaCl
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Analgesics. 1. Synthesis and analgesic properties of N-sec-alkyl- and N-tert-alkylnormorphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.98 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415284 | NALORPHINE | 2.0 | 1 | 8.22 |
| CHEMBL3275471 | — | — | 1 | 7.85 |
| CHEMBL3275464 | — | — | 1 | 7.60 |
| CHEMBL3275467 | — | — | 1 | 7.35 |
| CHEMBL3275461 | — | — | 1 | 7.21 |
| CHEMBL3275463 | — | — | 1 | 7.10 |
| CHEMBL3272387 | — | — | 1 | 7.04 |
| CHEMBL3275462 | — | — | 1 | 6.96 |
| CHEMBL3275470 | — | — | 1 | 6.90 |
| CHEMBL3275468 | — | — | 1 | 6.89 |
| CHEMBL3275472 | — | — | 1 | 6.88 |
| CHEMBL3275469 | — | — | 1 | 6.82 |
| CHEMBL3275466 | — | — | 1 | 6.76 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.60 |
| CHEMBL3275465 | — | — | 1 | 6.47 |
| CHEMBL3275460 | — | — | 1 | 6.00 |
| CHEMBL3275458 | — | — | 1 | 6.00 |
| CHEMBL3275459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415284 | NALORPHINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3275471 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3275464 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3275467 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3275461 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3275463 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3272387 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3275462 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3275470 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3275468 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3275472 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3275469 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3275466 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL70 | MORPHINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3275465 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3275460 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3275458 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3275459 | — | IC50 | > | 1000.0 | nM | - |